SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM: A LIPID BASED DRUG DELIVERY SYSTEM
Keywords:SMEDDS, Surfactant, Cosurfactant, Lipophilic, Hydrophobic
The self-micro-emulsifying drug delivery systems (SMEDDS) are developed to enhance solubility, absorption and bioavailability of poor water-soluble drugs. The globule size between 0-100 nm. Due to poor of lipophilic or hydrophobic drug absorption and dissolution causes least or minimal oral bioavailability. Thus, not able to achieve intended therapeutic effect of the poor water-soluble drugs will led to discover and develop novel drug delivery systems which will fulfill by this route led to development of novel drug delivery systems that will fulfill therapeutic needs with minimum dose of drug. SMEDDS are employed to enhance oral absorption of highly lipophilic compounds. The multiple-lipid based drug delivery systems are widely reported in literature. In multiple lipid-based drug delivery systems include coarse, dry and multiple emulsions and more complex micro emulsifying, Self emulsifying, nano emulsifying drug delivery system.
- 06/15/2022 (2)
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