FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF EDOXABAN BY SOLID DISPERSION METHOD

Abstract

Drugs in sublingual tablets are delivered under the tongue and directly into the bloodstream through the ventral surface of the tongue and the bottom of the mouth. The drug was rapidly absorbed via the reticular vein under the buccal mucosa and transported before being excreted into the systemic circulation via the facial, internal jugular, and brachiocephalic veins. They vary in size, shape, and weight, depending on the number of active ingredients and route of application. Most medicines are available in tablet form, depending on the stability of the active pharmaceutical ingredient. There are dosage and administrations such as swallowing whole tablets, chewable tablets, dispersible tablets, and sublingual tablets. Edoxaban is practically insoluble in water. Therefore, we considered improving the solubility of edoxaban with a solid dispersion and making it into a sublingual tablet. In vitro dissolution testing in phosphate buffer pH 6.8 using a USP type II apparatus showed that solid dispersions prepared by a melt process using polyethylene glycol 6000, a water-soluble carrier, significantly improved in vitro dissolution testing. This study shows that increasing the carrier concentration increases the dissolution rate (1:4 ratio). In vitro release studies have shown that solid dispersion formulations release active ingredients faster than physical mixtures and pure active ingredients. IR spectrophotometry was used to study drug excipient compatibility.