AN OVERVIEW OF SUBLINGUAL ROUTES FOR DRUG DELIVERY & THEIR APPLICATION

Abstract

Oral administration is one of the most convenient forms of drug delivery due to its ease of administration, painlessness, versatility and excellent patient compliance. The demand for rapidly disintegrating tablets has increased over the past decades, especially for geriatric and pediatric patients with aphasia. The demand for rapidly disintegrating tablets has increased over the past decade due to the properties of rapidly disintegrating sublingual tablets for potential emergency treatment. Regarding permeability, the sublingual region of the oral cavity (that is, the bottom of the mouth) is more permeable than the buccal (cheek) region, which is more permeable than the palate (palate). Administration of drugs via oral mucosa is considered a promising alternative to oral administration. These tablets disintegrate and dissolve quickly in saliva due to interaction with salivary enzymes. Administration of drugs via the sublingual route arose from a desire to provide immediate onset of pharmacological action. Dysphagia (difficulty swallowing) is a common problem of all ages, especially the elderly, pediatrics, and patients who are mentally retarded, uncooperative, nauseous, or undergoing restrictive fluid intake/diet. and these dosage forms are difficult to swallow.