FORMULATION AND EVALUATION OF A MUCOADHESIVE BUCCAL TABLET OF TELMISARTAN

Authors

  • Shital Misal Student
  • Jaydeep Pawar Professor
  • Dhananjay landge Professor

DOI:

https://doi.org/10.5281/zenodo.8018232

Keywords:

Telmisartan., Buccal tablet., Mucoadhesive, Drug Release., HPMC K4M Etc.

Abstract

Buccal route of administration has many advantages such as improving patient compliance, bypassing the GIT and hepatic first pass effect. The objectives are to formulate mucoadhesive buccal tablet using Telmisartan and compatible excipients, and to evaluate the product using quality control tests and in vitro tests. The ingredients were subjected to Fourier Transform Infrared Spectroscopy studies for compatibility test and the results showed no interaction. Two batches of Telmisartan tablet were prepared. The tablet thickness and diameter are 5.80 mm and 14 mm respectively. All tablets are within the specification of +/- 5%. The in-house tablet hardness is 5-15 kg and percent friabilation is not more than 0.8%. The disintegration test showed that all tablets disintegrated within 2 hours. The content uniformity showed that tablets are within the range of 85%-115%. The tablet weight is within the 5% range. The percent swelling is 53.83% to 58.86% and moisture absorption is 11.79% to 14.56%. The surface pH of the tablet is close to the salivary pH, which means that it would not irritate the buccal mucosa. The buccal tablet has a mucoadhesiveness of 0.196 to 0.200. There was no change in pH and size after subjecting it to stability studies in human saliva. Drug release studies showed 87.7% to 97.4% after 3 hours. Even after 3 months of subjecting the tablets to 40 ºC and 75% RH, results are within acceptable range. The results show the potential of the formulation as a mucoadhesive buccal tablet

Author Biographies

Shital Misal, Student

HSBPVT's GOI faculty of pharmacy, Kasthi Tal. Shrigonda,  Dist. Ahmednagar.

Jaydeep Pawar, Professor

HSBPVT's GOI faculty of pharmacy, Kasthi Tal. Shrigonda,  Dist. Ahmednagar.

Dhananjay landge, Professor

HSBPVT's GOI faculty of pharmacy, Kasthi Tal. Shrigonda,  Dist. Ahmednagar.

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Published

07/31/2022

How to Cite

1.
Misal S, Pawar J, landge D. FORMULATION AND EVALUATION OF A MUCOADHESIVE BUCCAL TABLET OF TELMISARTAN. ijcrips [Internet]. 2022 Jul. 31 [cited 2024 Feb. 29];1(1):53-60. Available from: https://ijcrips.com/index.php/files/article/view/19

Issue

Section

Review Article